Identifying Causal Genes and Dysregulated Pathways in Complex Diseases
Figure 2
Lists of selected target, causal and hub genes.
Target and hub genes that are labeled red were up-regulated while genes labeled green were down-regulated. Causal genes are marked in red (green) if they were found in amplified (deleted) genomic regions. We defined hubs as genes that appeared in more than 10 causal pathways through the interaction network. Numbers in parentheses indicate the genes' actual occurrences.