A Hybrid Model of Mammalian Cell Cycle Regulation
Figure 3
Model predictions of cyclin E dynamics.
(A) Scatter plots. (B) Stochastic limit cycle in the state space of cyclins A, B and E. We provide two different perspectives of this three dimensional figure to help visualize how the cyclin levels go up and down. In addition, we have added golden-colored balls to help guide the eye along the cell cycle trajectory. Each ball represents the average of the cyclin levels of all the cells binned over a hundredth of the φi interval [0,1], where φi refers to the fraction of the cell cycle completed by cell i (as described in the Methods section). Finally, it may help to recognize that Fig. 2E is a projection of the data on the CycA-CycB plane, and Fig. 3B is a projection on the CycA-CycE plane.