A Hybrid Model of Mammalian Cell Cycle Regulation
Figure 2
(A,C,E) Flow cytometry data from Yan et al [42]. DNA = 190 corresponds to G1 and DNA = 380 corresponds to G2/M. (B,D,F) Our simulations. We are plotting the total amount of cyclin A and cyclin B per cell, i.e., [CycA]·M(t) and [CycB]·M(t). DNA = 1 in G0/G1 phase; = 2 in G2/M phase. Some ‘instrumental noise’ has been added to the calculated levels of cyclins and DNA, as described in the Methods. The arrows in (A, B) indicate the rate of cyclin B accumulation in S phase in the measurements and in the model. The arrows in (C, D) indicate the cyclin A level at the onset of DNA synthesis, compared to the maximum expression level of ∼600 AU.