Integrative Features of the Yeast Phosphoproteome and Protein–Protein Interaction Map
Figure 3
Node degree distributions of phosphoproteins and nonphosphoproteins in the phospho-PPI data sets of “ALL” (A–C) and “Y2H” (D–F).
(A,D) Cumulative probability distribution of node degrees. For each group of phosphoproteins and nonphosphoproteins, circles represent proportions of proteins with more than the k interacting partners indicated on the horizontal axis [P≥(k)]. (B,E) P to N (P/N) ratio, where P and N are P≥(k) of phosphoproteins and nonphosphoproteins, respectively. (C,F) O to E (O/E) ratio, where O is P≥(k) of phosphoprotein and E is that expected from negative controls generated by node label shuffling (N = 10,000). For each node degree level, line graph and bar represent mean and two-sided 95% confidence intervals, respectively. Background colors and asterisks denote statistical significance over neutral O/E value of 1.0 (*P<0.05, **P<0.01, ***P<0.001).