Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells
Figure 8
(A) The pharmacokinetic model for plasma and intracellular MTX and MTXPG [9]. The parameters are defined in the text. The dashed line describing the efflux of intracellular MTX back to the plasma represents the fact that the system is uncoupled, i.e. we account for the efflux of intracellular MTX but we do not explicitly account for its return to the plasma. (B) The folate pathway model [12] is modified to include the pathways inhibited by MTXPG. The model parameters (described by arrows) are defined in the text and supplemental material.