Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells
Figure 7
Simulations of the effects of lineage and dosage on model estimated DNPS activity.
The curves represent the median and the shaded regions represent the quartiles of the results from the respective simulated patient populations. (A) Simulated percent change in DNPS vs time after a 1 g/m2 dose of MTX. Solid curve and Red shading: B-lineage Hyperdiploid; Dashed curve and Blue shading: T-lineage. (B) Simulated percent change in DNPS at 42 hrs vs Dose. Solid curve and Red shading: 24 hr MTX infusion; Dashed curve and Blue shading: 4 hr MTX infusion.