Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells
Figure 3
MTX metabolizing enzyme model parameters vs ALL subtype.
(A) VMAX FPGS vs molecular subtype. (B) NET-PG (net accumulation of MTXPG) vs molecular subtype. Median, quartiles, non-outliers range (defined as 1.5 times the interquartile range), and outliers (plus-marks) are depicted. The subtypes are defined as follows: BHD, B-lineage hyperdiploid ALL; BNHD, B-lineage non-hyperdiploid without the t(12;21) [ETV6-RUNX1] or t(1;19) [TCF3-PBX1] translocation; ETV6-RUNX1, B-lineage non-hyperdiploid with the t(12;21) [ETV6-RUNX1] translocation; TCF3-PBX1, B-lineage non-hyperdiploid with the t(1;19) [TCF3-PBX1] translocation; and T, T-lineage ALL.