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Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

Figure 2

MTX net influx vs ALL ploidy.

NET-influx (model parameter describing the net influx of MTX) vs ALL ploidy (hyperdiploid vs non-hyperdiploid). Median, quartiles, non-outliers range (defined as 1.5 times the interquartile range), and outliers (plus-marks) are depicted for B-lineage ALL.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1001019.g002