Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells
Figure 1
MTX and MTXPG concentration vs time plots.
(A) Plasma MTX concentration (µM) vs time (hrs). (B) Intracellular MTX (MTXPG1) concentration in peripheral blood cells (pmol/109 cells) vs time (hrs). (C) Intracellular MTXPG2-7 concentration in peripheral blood cells (pmol/109 cells) vs time (hrs). Black lines and circles represent the model fit and data given a 24 hour infusion and green lines and dimonds represent the model fit and data given a 4 hour infusion. We plotted the MTXPG concentrations at fixed time points around each sampling time to prevent the samples from the two different infusion groups from overlapping.