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Modeling Conformational Ensembles of Slow Functional Motions in Pin1-WW

Figure 5

Betweenness centrality based kinetic network for the simulation ensemble Extended 2.

In this kinetic network nodes represent macrostates, edge widths are proportional to their betweenness measure . If an edge is thicker then it means that this edge belongs to several shortest paths among pairs of macrostates. Node size depends on the macrostate population. A node colored blue is closer, in RMSD terms, to the Apo Pin1-WW conformation and a red node is closer to the Holo Pin-WW structure. Figure created using Cytoscape [52].

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1001015.g005