Non-Centered Spike-Triggered Covariance Analysis Reveals Neurotrophin-3 as a Developmental Regulator of Receptive Field Properties of ON-OFF Retinal Ganglion Cells
Figure 6
The number of ON-OFF cells decreases with age.
(A) Cumulative distribution of the absolute value of the STC-NC bias for WT P18 and P25. A lower percentage of cells with ON-OFF character are observed in P25 retina (p = 0.003 in K-S Test). (B) The percentages of ON, OFF, and ON-OFF RGCs classified based on their STC-NC Bias in WT retinas at P18 and P25. The distributions differed significantly (two sample χ2 p = 0.015), with P25 retina possessing fewer ON-OFF cells and a corresponding increase in ON cells. (C) No difference was observed in the percentage of cell types between WT and NT-3 OE retinas at P18 (two sample χ2 p = 0.366).