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Bistability in Apoptosis by Receptor Clustering

Figure 10

Model discrimination using hyperactive mutants.

The wildtype response curve, giving the steady-state active wildtype Fas fraction as a function of the FasL concentration (stable, solid lines; unstable, dashed lines), of the cluster model varies with the mutant population fraction , reflecting receptor interactions absent in the crosslinking model. The total receptor concentration is fixed at . All parameters set at baseline values unless otherwise noted.

doi: https://doi.org/10.1371/journal.pcbi.1000956.g010