< Back to Article

Bistability in Apoptosis by Receptor Clustering

Figure 9

Cell-level cluster integration.

The apoptotic signals of all Fas clusters are integrated to produce a normalized cell activation . The resulting hysteresis curve on as a function of the FasL concentration is graded due to the heterogeneity of the bistability thresholds across the clusters (top). Despite this variability, a strong linear dependence persists between (bottom; the valid region is shown in green).

doi: https://doi.org/10.1371/journal.pcbi.1000956.g009