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Bistability in Apoptosis by Receptor Clustering

Figure 3

Steady-state activation curves.

The steady-state active Fas concentration shows bistability and hysteresis as a function of the FasL concentration (stable, solid lines; unstable, dashed lines). At low receptor concentrations , the bistability is reversible, but irreversibility emerges for sufficiently high, representing a committed cell death decision. All parameters set at baseline values unless otherwise noted.

doi: https://doi.org/10.1371/journal.pcbi.1000956.g003