Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood
Figure 7
Effect of anti-XI and anti-XII.
Addition of 50 µg/ml of anti-XI and anti-XII will completely prevent initiation of clotting in resting blood showing that initiation is a result of leak past saturated effects of CTI. However, on CVX activated platelets initiation is still unaffected by the presence of both CTI and these antibodies. Initial thrombin production during the propagation phase is however diminished due to abolition of thrombin feedback on FXI. Insert shows initial rates of thrombin formation in the presence of these antibodies.