Correlated Mutations: A Hallmark of Phenotypic Amino Acid Substitutions
Figure 6
Correlation patterns in the adenylate kinase isoenzyme 1.
(A) circular representation of linear protein sequence. Arcs indicate residue correlations. (B) Structure view indicating selected correlations as dashed lines (PDB: 2C95). (A,B) Disease associated positions are marked red, functional sites in blue.