Correlated Mutations: A Hallmark of Phenotypic Amino Acid Substitutions
Figure 5
Correlation patterns in the human proline peptidase PEPD.
(A) circular representation of linear protein sequence. Arcs indicate residue correlations. (B) Structure view indicating selected correlations as dashed lines. Metal binding residues are shown with side chains (PDB: 2iw2). (A,B) Disease associated positions are marked red, functional sites in blue.