The Distinct Conformational Dynamics of K-Ras and H-Ras A59G
Figure 2
Results of principal component analysis (PCA) on the Ras catalytic domains reveal the relationship between K-Ras and other H-Ras crystal structures.
Structures are projected onto the first three principal components (PC) with the largest variances and colored based on the dominant grouping obtained from hierarchical clustering of the projected structures. Representative structures corresponding to distinct bound-nucleotides, wild-type or mutant states, and different isoforms are labeled with their PDB IDs.