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Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

Figure 6

Illustration of Bayesian probability approach.

(A) Distributions of GNa with different constraints. From left to right, histograms show GNa values in the complete data set; given that APD is in a particular range (from 295–298 ms, representing 10% of the samples); given that APD and Vrest (−84.96 to −85.02 mV) are in particular ranges; given that APD, Vrest, and Vpeak (37.05 to 37.81 mV) are in particular ranges. (B) Distributions of GCa, given the same constraints as in (A).

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1000914.g006