MetMap Enables Genome-Scale Methyltyping for Determining Methylation States in Populations
Figure 5
Strongly Unmethylated Islands (SUMIs) in the neutrophil methylome.
Genomewide SUMI predictions (a) reveal strongly unmethylated islands that are proximal to genes and that do not always correspond to sequence-based annotations of CpG islands shown in the tracks ‘BF islands’ and ‘CpG islands’ (e.g., the promoter of LRG1 and in an intron of SH3GL1). (b) SUMI and BF island length distributions have a different shape than the CpG island length distribution, suggesting numerous short false positives in the latter. (c). Some SUMIs appear 5′ of alternative promoter sites.