Patterns of HIV-1 Protein Interaction Identify Perturbed Host-Cellular Subsystems
Figure 7
HIV-1-host interaction patterns, by HIV-1 protein.
This network illustrates core patterns of HIV-host interaction. The human host is depicted as a series of cellular subsystems, represented by orange circular nodes, where the diameter of the node is proportional to the number of host proteins within that subsystem. HIV-1 is depicted by the viral proteome (blue triangles). Interactions between HIV-1 proteins and host subsystems are represented by edges, where the edge width is proportional to the number of interactions. For clarity, only those interactions that are shared by over half of the host proteins in a subsystem are shown. *Indicates a host subsystem whose subsystem annotation corresponds to a statistically significant group among HDFs ().
Indicates a statistically significant intersection between the subsystem proteins and HDF set (
).