Patterns of HIV-1 Protein Interaction Identify Perturbed Host-Cellular Subsystems
Figure 6
These networks represent the pattern of cytokine regulation in the cytokine-activity host subsystem that were defined through identifying significant patterns of HIV-host interaction. Edges represent PPIs. Edge width is proportional to the number of PPIs being represented. For clarity, we only show PPIs that are reported more than once in the HHPID. These networks show that cytokine dysregulation due to HIV-1 infection is wide reaching and complex, affecting many host cytokines, both via upregulation (left) and downregulation (right).