Patterns of HIV-1 Protein Interaction Identify Perturbed Host-Cellular Subsystems
Figure 4
Comparison of protein pairs within significant biclusters to other protein pairs.
Panels A, B and C show the semantic distance distributions for the three GO ontologies: biological process, cellular component and molecular function, respectively, for (i) human protein pairs from significant biclusters (shown in grey) and (ii) all other human protein pairs from PBPs (shown in black). Panel D shows the pairwise sequence similarity distributions for (i) and (ii). These charts show that human proteins from within significant biclusters are more similar in their GO annotation and sequence than other protein pairs ( in a Mann-Whitney U test, in all cases).