Large-Scale Analysis of Network Bistability for Human Cancers
Figure 2
Motifs of bistable toggle switches.
A type-1 bistable toggle switch (BTS) contains two genes with positive autoregulation. Each gene mutually inhibits the other's expression. The two genes in the type-2 BTS also suppress each other's expression. Each gene has double positive or negative feedback with the other gene, so the same function as a type-1 BTS may be exhibited. A type-3 BTS was constructed on the basis of a theoretical study on the modeling of genetic switches with positive feedback loops. The blue, green, and orange nodes respectively correspond to switch genes, mediators, and genes constituting a feedback loop. Positive (upregulated) interactions are indicated by green lines and negative (downregulated) interactions are indicated by red lines.