Computer Simulation of Cellular Patterning Within the Drosophila Pupal Eye
Figure 6
Adhesion did not affect formation of 2°s or 3°s in the presence of cell death.
All images are final images from 50,000 MCS trials. (A) In a simulation in which IPCs were more adherent to OCs than to each other, 3°s and most 2°s emerged correctly at all central ommatidia. Several ectopic end-to-end 2°-like cells are indicated (•) (B) In a simulation in which OC:IPC and IPC:IPC adhesion was set as identical, 3°s still correctly emerged within all central ommatidia. An increase in cell death resulted in some missing 2°s (arrowheads). (C) 3°s also emerged within a simulation in which IPCs were more adherent to each other than to OCs; occasional loss of 3°s was observed (arrow). Increased cell death (PCD) resulted in missing 2°s (arrowheads). Asterisks label enlarged ommatidia (insets). (D and E) Graphs quantifying how in the presence of reduced cell death (L = 10), preferential adhesion most efficiently enhanced the ability of 2°s (D) and 3°s (E) to form. Each line represents the result of a single representative simulation from at least two repetitions. When OC:IPC adhesion was the same (‘flat adhesion’) or less (‘anti-preferential adhesion’) than IPC:IPC adhesion 2°s and 3°s still formed though less efficiently.