Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses
Figure 10
Alteration in mTOR sensitivity to low ATP levels introduced in steps of +/−5% have a significant effect on lifespan, as indicated by the length of simulations runs carried out until oxidized protein concentrations reach a critical level. Changes do not increase in proportion to higher degrees of perturbations. It is noted that mTOR activities at positive changes from the baseline (black line) can initially decline, but increase later. Stronger inhibition of mTOR slows accumulation of oxidized proteins, but reduces other fitness parameters such as ATP consumption (dotted magenta line) that may negatively impact physiological functions.