Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses
Figure 7
In this version of the AR model NF-κB is inhibited from a mid-point time on. The scavenging role of NF-κB and its role in mitochondrial regulation, along with increased biosynthesis by ROS activation of mTOR, cause an instant improvement of metabolic functions moving the cell to a “younger state”, consistent with NF-kB blockade experiments. However, the model prediction after this point in time has the characteristic of a vicious cycle with accelerated decline not improving lifespan.