Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses
Figure 5
Fuzzy-logic simulation of a model including NF-κB.
In this simulation the VC-model is extended towards an adaptive response (AR) model by introducing the NF-κB pathway that protectively upregulates ROS scavengers and downregulates mitochondrial function. Compensatory upregulation of aerobic glycolysis diverts ATP consumption from mitochondrial respiration. Model lifespan is only slightly extended and the model still shows an accelerated decline.