Revisiting Date and Party Hubs: Novel Approaches to Role Assignment in Protein Interaction Networks
Figure 4
Rolewise hub avPCC distributions.
Plots show node role versus average expression correlation with partners for hubs in yeast (FHC [4]—553 hubs with a minimum degree of 7) and human (CCSB-HI1 [49]—326 hubs with a minimum degree of 4) networks. Larger circles represent means over all nodes in a given role. Note that ‘hub’ as used in the role names refers only to within-community hubs, but all of the depicted nodes are hubs in the sense that they have high degree. In each case, we determined the degree threshold so that approximately the top 20% highest-degree nodes are considered to be hubs. We also fixed the date/party avPCC threshold at 0.5, in accordance with Bertin et al. [4].