Mathematical Modelling of DNA Replication Reveals a Trade-off between Coherence of Origin Activation and Robustness against Rereplication
Figure 3
Sensitivity to variations in protein concentrations.
(A) Control coefficients for the total number of fired origins N, the mean time to firing t, the duration of firing Δ, and the number of rereplicating origins ρ, calculated for the concentration of each protein component (mean value and standard deviation for admissible parameter sets). (B) Total number of firing origins N, mean time to firing τ and the duration of firing Δ are robust network responses, whereas the number of rereplicating origins ρ is very vulnerable against fluctuations in the protein concentrations. (C) Fast origin activation increases the probability for rereplication. Colour code indicates the vulnerability to rereplication.