Impact of Dendritic Size and Dendritic Topology on Burst Firing in Pyramidal Cells
Figure 6
Dendritic topology influences burst firing, as demonstrated in the set of morphologically simplified neurons (Fig. 2) using somatic stimulation.
The segment diameters in the trees obey Rall's power law. A, Examples from the set of 23 tree topologies together with corresponding voltage traces. Each tree has a total dendritic length of 1750 µm. Scale bar: 100 ms, 100 mV. B, The range of tree sizes where burst firing occurs is modulated by dendritic topology. For all the 23 tree topologies, the degree of bursting is shown as a function of the total length of the dendritic tree, plotted with an offset (for all horizontal lines B = 0) for clarity. The topologies are ordered as in Fig. 2, with the top line representing topology 1, and the bottom line topology 23. The total dendritic length of a given tree topology was varied by multiplying the lengths of all its segments by the same factor. C, Bursting as a function of topology at a total dendritic length of 1750 µm. D, For topology 1, voltage traces at different total dendritic lengths, together with B values indicating the degree of bursting. From top to bottom: 1000, 1300, 1600, 1900, 2200, 2500, and 2800 µm. Scale bar: 100 ms, 100 mV.