Impact of Dendritic Size and Dendritic Topology on Burst Firing in Pyramidal Cells
Figure 5
Both with somatic and with dendritic stimulation, dendritic topology affects pyramidal cell burst firing.
Using the cell from Fig. 1A, we varied the topology of the apical dendritic tree by swapping branches within the tree. Thus, all the pyramidal cells shown have exactly the same total dendritic length and dendritic surface area and differ only in the topology of their apical dendrite (basal dendrites are the same). Voltage traces for three bursting cells (A–C), and three non-bursting cells (D–F). Scale bar: 100 ms, 50 mV. Scale bar (anatomy): 100 µm. MEP values indicate the mean electrotonic path length of the apical dendritic tree.