Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma
Figure 6
Predictions of the two-compartment model for a PPD bead granuloma.
(A) The effects of receptor binding, intracellular trafficking of TNF and cellular organization within granuloma (represented by separation) on the steady state spatial distribution of free sTNF in a granuloma. (B) The effect of separation between different cell types in a granuloma on the spatial concentration of sTNF-bound cell surface TNFR1. Parameter values for the rate of mTNF synthesis (and similarly for TNFR densities) in each compartment were computed via Equations 6 and 7, using experimental data for day 4 granulomas presented in Figure 4 and Tables 7 and 8. Other parameter values are as listed in Table 3. The qualitative aspects of these plots are similar for day 2 granulomas.