Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma
Figure 5
Quantification of the rate of mTNF synthesis by each cell type.
Experimental data on the number of mTNF molecules on the surface of each cell type after addition of TAPI-1 were fitted to Equation 10 to estimate ksynth for that cell type. Displayed data represent TNF synthesis by day 4 granuloma cells for three hours in the presence of TAPI-1. Error bars indicate standard deviations. Values of R2 for curve fitting for mDCs, macrophages and pDCs are 0.97, 0.99 and 0.98, respectively.