A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies
Figure 4
Number of probes with an eQTL found as a function of maximum number of hidden factors for three previously published datasets.
Significance-testing based methods (PCAsig, SVA) identified the same number of factors for a wide range of cutoff values (), thus only a single count is given (dashed lines), together with the number of factors found (diamond shape). Other methods were applied with a maximum number of
,
,
and
hidden factors.