Simulating Microdosimetry in a Virtual Hepatic Lobule
Figure 8
Average concentration throughout lobule for the five morphologies depicted in Figure 3.
The ensemble average for all five lobules is very similar to the well-mixed lobule prediction (indicated by the dashed line) however the different morphologies produce different whole-liver clearances because the number of hepatocytes as a fraction of the volume of the simulated lobule is geometry-dependent.