Simulating Microdosimetry in a Virtual Hepatic Lobule
Figure 7
A physiologic lobule is a three-dimensional polyhedron with a volume between 0.1 and 0.9 µL [8].
Our (quasi-)two-dimensional simulated lobule is assumed to have a thickness equal to a sinusoidal diameter (23.5 µm [29]). Therefore many identical simulated lobules in parallel are needed to fill the volume of one physiologic lobule. Blood flow to the simulated lobules is divided by Rliv∶lob, the ratio of the volume of the whole liver to the volume of single lobule.