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Ion Channel Density Regulates Switches between Regular and Fast Spiking in Soma but Not in Axons

Figure 4

Prerequisites for three stationary potentials (defining region C1).

Steady-state currents versus membrane voltage for the hippocampal neuron model. Calculated from Equation 17. The Na channel density is varied while other parameters are maintained constant to demonstrate the requirement of a high Na channel density to obtain three stationary potentials. Inward currents are shown as positive. (A) = 30 µm/s and = 5 µm/s. (B) = 11 µm/s and = 5 µm/s.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1000753.g004