A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants
Figure 5
The roles of replication space (T) kinetics to model estimates.
Two cases of T dynamics were examined: first, T synthesis rate s was estimated (range: [0.01–1] h−1) simultaneously with other parameters; second, s was fixed to 1 h−1. Panel a, Maximum likelihood objective function values for both cases. Majority of values are within the objective function differences expected from likelihood ratio for one additional parameter estimated. Panel b, Boxplot of synthesis s values. Panel c, Boxplot of log10 of reproductive ratio. Estimates of reproductive ratio is lower when s is higher (when s was fixed to its upper bound of 1 h−1). Panel d, Fitness fi for both cases. Similar values suggests robustness to assumed synthesis rate s in both cases. Panels e–f, Boxplot of fitness f values of two representative variants T54A and A156T for both cases.