A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants
Figure 4
Comparison between data and best-fit models for alternative cases of replication space T dynamics applied to Subject 1.
Panel a, comparison for plasma HCV RNA. Panel b, comparison for variant prevalence composition. Legends: black lines, overall HCV RNA load; grey lines, fraction of available replication space T/Tmax; colored lines, contribution of variants to HCV RNA load; solid lines, T followed Equation 1 and s was optimally estimated at 0.03 h−1; dashed lines, T followed Equation 1 and s was fixed at 1 h−1; dotted lines, T followed Equation 8 and γ was fixed at 0.05 h−1 — a value comparable to s = 1 h−1 in Equation 1. Alternative representations of similar rate of increase in replication space T provide qualitatively similar fits to data.