A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants
Figure 2
Correspondence between in vitro replicative fitness and in vivo fitness computed using two alternative methods.
Panel a, in vivo fitness computed using modeling proposed here. Panel b, in vivo fitness computed using the Relative Fitness method. The in vitro fitness was measured in replicon cells and has been reported in [16], [17]. When compared to fitness estimates in vitro, in vivo fitness estimates from modeling correspond better than the estimates from the Relative Fitness method. Relative Fitness was computed as the ratio of rate of change of viral loads (in log-scale) between a variant and wild-type (see methods).