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Temperature Control of Fimbriation Circuit Switch in Uropathogenic Escherichia coli: Quantitative Analysis via Automated Model Abstraction
Figure 7
Regulation of the ON-to-OFF fim circuit switching probability via temperature control.
The detailed model was used to evaluate ON-to-OFF switching probabilities over one cell generation at the three temperature points (
, 
, and 
), where experimental measurements had been made previously [30]. Calculations were repeated using the abstracted model at these and seven additional temperature points (
, 
, 
, 
, 
, 
, and 
) – all in minimal medium. Here, (A) Wild-type (
and 
) ON-to-OFF switching probability per cell per generation is plotted versus temperature; and (B) Same, but for 
-only mediated switching, where further points (
, 
, 
, 
, 
, 
, 
, and 
) were added to increase resolution around the physiological temperature peak. (Error bars in (A) and (B) indicate 95% confidence interval.)
doi: https://doi.org/10.1371/journal.pcbi.1000723.g007