Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules
Figure 4
Response of host cells to treatment () as a function of treatment time
and S phase duration
.
(A) TATO, as given by Eq. 1 with sinusoidal. (B) Numerical simulations of the full model. The response is normalized from low tolerance (blue) to high tolerance (red). Daily extrema predicted by TATO are indicated by white lines (dashed: highest toxicity
, solid: lowest toxicity
, same in both panels). TATO predicts well the location of the extrema of the full model (squares: highest toxicity
; circles: lowest toxicity
). At
= 24 h, the location of extrema are shifted by 12 h (thick vs. thin lines).