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Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules

Figure 3

Treatment outcomes as a function of circadian time of administration.

(A) Fast growing tumor treated at optimal time 2:00. (B) Best treatment outcome for fast growing tumors (maximal ) is at 2:00, while the worst is at 17:30 (thick line). (C) Slow growing tumor treated at optimal time 22:00. (D) Best treatment outcome for slow growing tumors is at 22:00, while the worst is at 5:30 (thick line).

doi: https://doi.org/10.1371/journal.pcbi.1000712.g003