Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules
Figure 2
Daily evolution of the host, fast growing tumor and slow growing tumor.
(A) S phase fraction. (B) G0/G1 phase fraction. (C) G2/M phase fraction. Dark phases are indicated by black bars (20:00 to 8:00). In panels A–C, time 0 corresponds to 72 h after beginning simulations, to allow for transients to vanish. Initial conditions (at h) are
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. In panels A–C, solid lines denote host, dashed lines fast growing tumor, and dashed-dotted lines slow growing tumor.