A Multiscale Model to Investigate Circadian Rhythmicity of Pacemaker Neurons in the Suprachiasmatic Nucleus
Figure 6
Cytosolic calcium levels regulate circadian behavior.
Circadian profiles of Per mRNA (A) and firing rate (B) are shown for the control (black line), 50% reduced cytosolic Ca2+ concentration (red dashed line) and 50% increased cytosolic Ca2+ concentration (blue dotted line) compared to the control. C). Per mRNA (red dashed line) and firing rate (black solid line) amplitudes as a function of the cytosolic calcium concentration. D). The period of the core oscillator as a function of the cytosolic calcium concentration. The circles in 6C and 6D represent nominal values of the model.