A Multiscale Model to Investigate Circadian Rhythmicity of Pacemaker Neurons in the Suprachiasmatic Nucleus
Figure 4
GABA concentrations affect the circadian oscillatory behavior.
A). % IPSC change during the subjective night (black solid line) and day (red dashed line) as a function of % GABA decrease B). % firing frequency change during the subjective night (black solid line) and day (red dashed line) as a function of % GABA decrease. C) % IPSC change during the subjective night (black solid line) and day (red dashed line) as a function of % GABA increase. D). % firing frequency change during subjective night (black solid line) and day (red dashed line) as a function of % GABA increase. E). Circadian profiles of the firing frequency are shown for the control (black line), complete GABA blockade (red dotted line) and maximum GABA application (blue dashed line).