A Multiscale Model to Investigate Circadian Rhythmicity of Pacemaker Neurons in the Suprachiasmatic Nucleus
Figure 3
Intracellular calcium dynamics affect the circadian oscillatory behavior.
Circadian profiles of the firing rate (A), intracellular calcium concentration (C) and Per mRNA concentration (D) are shown for the control (black line), ryanodine blockade (red dashed line) and nimodipine application (blue dotted line). B). % decrease in the firing rate, Per mRNA concentration, Ca2+ current (ICa) and cytosolic calcium concentration during the circadian night (green bars) and day (red bars) as a result of ryanodine blockade. E) % decrease in the firing rate, Per mRNA concentration, Ca2+ current (ICa) and Ca2+ -activated K+ current (IKCa) during the circadian night (green bars) and day (red bars) as a result of nimodipine application. ** denotes very small changes of the perturbed value compared to the control.