Estimating the Stochastic Bifurcation Structure of Cellular Networks
Figure 7
Comparison of goodness-of-fit between methods and biological replicates.
(A) For each method, the mean negative log likelihood of the data. “Training” means each model is evaluated on the same data to which it is fit, whereas “testing” means each model is evaluated on the data from the other three replicates having the same pregrowth condition. Black bars indicate 95% confidence intervals. (B,C) Variability in the estimated locations of four subpopulations: the low (and only) subpopulation at the zero galactose concentration (P1), the low subpopulation at the galactose concentration (P2), the high subpopulation at the
galactose concentration (P3), the high (and only) subpopulation at the largest tested galactose concentration (P4). Cyan bars show the variability attributed to different estimation methods, whereas green bars show the variability attributed to different biological repliciates.