Estimating the Stochastic Bifurcation Structure of Cellular Networks
Figure 3
Results of mixture modeling on replicate one.
(A) Means of subpopulations, as extracted by: mixture models estimated by the expectation-maximization algorithm (EM), mixture models estimated by a combination of mode estimation and expectation-maximization (ME+EM), and a conditional mixture model estimated by expectation-maximization (CEM). The x-axis represents the 17 levels of galactose tested, in order of increasing concentration. The y-axis represents fluorescence channels of the flow cytometer, which are proportional to the logarithm of fluorescent intensity. Darker background shading represents more cells counted in the channel at the given galactose level. (B) Estimated mixture coefficients (prior probabilities) of the low subpopulation as a function of galactose concentration. (C) Estimated standard deviations of the Gaussian distributions representing low (darker) and high (lighter) subpopulations as a function of galactose concentration.